FRIDAY JUNE 14
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15:00 - 17:30
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Registration
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17:00 - 17:30
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Tea & Snacks
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17:30-17:50
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WELCOME ADDRESS AND INTRODUCTORY COMMENTS
Alexei Zavarzin (St. Petersburg University, Russia)
Kenneth Cowan (Eppley Institute for Research in Cancer, University of Nebraska Medical Center, U.S.A.)
Sergei Inge-Vechtomov (St. Petersburg University and Russian Academy of Sciences, Russia)
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17:50-18:50
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KEYNOTE LECTURE
Lawrence Loeb (University of Washington, USA) “Human cancers express a mutator phenotype: origin, consequences and targeting”
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19:15
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Dinner at restaurant “РесторанЪ” (Tamozhennyy per. 2; a five- minute walk from the conference venue)
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SATURDAY JUNE 15
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9:30-13:00
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DNA REPLICATION MECHANISMS AND FORK DYNAMICS
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9:30 - 9:55
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Luca Pellegrini (University of Cambridge, U.K.) “Mechanism for priming DNA synthesis in eukaryotic replication”
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9:55 - 10:00
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Discussion
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10:00 - 10:25
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Tahir Tahirov (Eppley Institute for Research in Cancer, U.S.A.) “Structure and function of human B family DNA polymerases”
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10:25 - 10:30
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Discussion
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10:30 - 10:48
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Erik Johansson (Umea University, Sweden) “Enzymatic properties of yeast DNA polymerase epsilon”
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10:48 - 11:10
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Coffee Break
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11:10 - 11:40
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Hiroyuki Araki (National Institute of Genetics, Japan) “Establishment of replication forks at origins”
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11:40 - 11:45
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Discussion
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11:45 - 12:03
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Helmut Pospiech (University of Oulu, Finland, and Leibniz Institute for Age Research - Fritz Lipmann Institute, Germany) “Distinctive activities of human replicative DNA polymerases during S phase – DNA polymerase epsilon, but not DNA polymerases alpha/delta are associated with lamins throughout S phase”
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12:03 - 12:21
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Amir Aharoni (Ben-Gurion University, Israel) “Tight regulation of PCNA-mediated DNA replication in S. cerevisiae”
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12:21 - 12:46
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Luis Blanco (Centro de Biologia Molecular Severo Ochoa, Spain) “PrimPol, an archaic DNA primase/DNA polymerase in human cells”
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12:46 - 12:51
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Discussion
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13:00
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Lunch at Sevilla restaurant at Sokos Hotel Palace Bridge
Round-table lunch for students and postdoctoral fellows: Meet a speaker
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14:00 - 17:00
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Free time
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17:00 - 18:30
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Poster session #1
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18:45 - 19:45
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Dinner at Sevilla restaurant at Sokos Hotel Palace Bridge
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20:00-22:00
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CELLULAR RESPONSES TO REPLICATION IMPEDIMENTS
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20:00 - 20:30
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Peter Burgers (Washington University School of Medicine, USA) “How do replication forks signal stress?”
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20:30 - 20:35
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Discussion
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20:35 - 21:05
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Helle Ulrich (Institute of Molecular Biology gGmbH, Germany) “Mechanism of ubiquitin-dependent DNA damage bypass”
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21:05 - 21:10
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Discussion
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21:10 - 21:27
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Haruo Ohmori (Gakushuin University, Japan) “REV7 versus MAD2”
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21:27 - 21:44
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Alena Makarova (Washington University School of Medicine, U.S.A.) “DNA polymerase ζ and Rev1-mediated mutagenesis in yeast”
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21:44 - 22:00
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Ekaterina Beloussova (Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Russia) “Multiply damaged sites repair: participation of BER and translesion DNA synthesis”
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SUNDAY JUNE 16
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9:30 - 13:05
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SHAPING THE GENOME BY MUTATION AND RECOMBINATION (PART I)
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9:30 - 10:00
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Svend Petersen-Mahrt (IFOM-Fondazione Istituto FIRC di Oncologia Molecolare, Italy) “DNA instability is enhancing genome dynamics in immunity and epigenetics”
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10:00 - 10:05
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Discussion
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10:30 - 10:35
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Youri Pavlov (Eppley Institute for Research in Cancer, USA) “Genome-wide mutation avalanches in diploid yeast cells”
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10:35 - 10:40
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Discussion
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10:40 - 10:58
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Andrei Chabes (Umea University, Sweden) “dNTPs and maintenance of genome stability”
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10:58 - 11:18
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Coffee break
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11:18 - 11:48
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Roel Schaaper (NIEHS, USA) “DNA precursors and DNA replication fidelity”
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11:48 - 11:53
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Discussion
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11:53 - 12:11
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Nicholas Burgis (Eastern Washington University, U.S.A.) “Removal of noncanonical purines from nucleoside triphosphate pools”
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12:11 - 12:41
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Bradley Preston (University of Washington, USA) “Genetic instability and cancer: Walking the mutator high wire”
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12:41 - 12:46
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Discussion
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12:46 - 13:04
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Iwona Fijalkowska (Institute of Biochemistry and Biophysics of the Polish Academy of Sciences, Poland) “Contribution of non-catalytic components of replisome to the final fidelity of replication”
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13:05
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Lunch at Sevilla restaurant at Sokos Hotel Palace Bridge
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14:00 - 17:00
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Free time
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17:00 - 18:30
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Poster session #2
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18:45 - 19:45
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Dinner at Sevilla restaurant at Sokos Hotel Palace Bridge
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20:00-22:05
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SHAPING THE GENOME BY MUTATION AND RECOMBINATION (PART II)
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20:00-20:50
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KEYNOTE LECTURE
Michael Lynch (Indiana University, USA) “Evolution of the mutation rate”
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20:50 - 21:00
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Discussion
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21:00 - 21:25
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Anna Malkova (Indiana University-Purdue University Indianapolis, U.S.A.) “Molecular mechanisms of genetic instabilities resulting from Break-Induced Replication”
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21:25 - 21:30
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Discussion
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21:30 - 21:48
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Martin Kupiec (Tel Aviv University, Israel) “Effect of nuclear architecture on the efficiency of double-strand break repair”
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21:48 - 22:06
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Andrei Kuzminov (University of Illinois at Urbana-Champaign, U.S.A.) “Ultraviolet-induced chromosomal fragmentation: pathways, mechanisms, and contribution to lethality”
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MONDAY JUNE 17
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9:30 - 13:05
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DIVERSE PATHWAYS IN HEREDITY AND DISEASE
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9:30 - 10:00
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Sergei Mirkin (Tufts University, U.S.A.) “Genome weak links”
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10:00 - 10:05
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Discussion
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10:05 - 10:35
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Polina Shcherbakova (Eppley Institute for Research in Cancer, USA) “Mutagenic replication in DNA damage response and human cancer”
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10:35 - 10:40
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Discussion
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10:40 - 11:00
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Coffee break
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11:00 - 11:30
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Richard Wood (University of Texas MD Anderson Cancer Center, USA) “Mammalian DNA polymerase ζ and cancer”
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11:30 - 11:35
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Discussion
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11:35 - 12:05
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Roland Lill (Philipps-Universitat Marburg, Germany) “The role of mitochondria and iron-sulfur protein biogenesis in genome stability and DNA metabolism”
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12:05 - 12:10
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Discussion
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12:10 - 12:28
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Shay Ben-Aroya (Bar-Ilan University, Israel) “Characterization of CIA2, a conserved gene with a role in maintaining the stability of chromosomes”
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12:28 - 12:58
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Yury Chernoff (Georgia Institute of Technology, U.S.A.) “Heritable variability at the protein level”
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12:58 - 13:03
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Discussion
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13:05
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Lunch at Sevilla restaurant at Sokos Hotel Palace Bridge
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14:00 - 15:00
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Free time
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15:00
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Boat trip to Peterhoff
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16:00 - 18:00
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Tour of Peterhoff Palace and Park
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18:00
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Banquet dinner at “Summer Palace” restaurant, St. Petersburg shosse, 130/7, Peterhoff
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After the end of the banquet - return to the hotels by buses
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