Научные интересы:

Поиск и разработка новых противовирусных средств среди синтетических и природных соединений. Разработка и использование животных моделей вирусных инфекций для оценки противовирусного потенциала соединений in vivo. Изучение устойчивости вирусов к клиническим и экспериментальным соединениям.

Читаемые курсы:

• Спецкурс «Вирусы животных» (2-й семестр магистратуры)

Руководитель 2 защищенных и 5 выполняемых диссертационных работ по специальности «вирусология» в области разработки новых противовирусных препаратов. Руководитель более 40 бакалаврских и магистерских работ. Автор 196 публикаций в отечественных и международных профильных журналах. Автор 24 патентов РФ на изобретение.

Избранные публикации:

• Zarubaev VV, Pushkina EA, Borisevich SS, Galochkina AV, Garshinina AV, Shtro AA, Egorova AA, Sokolova AS, Khursan SL, Yarovaya OI, Salakhutdinov NF. Selection of influenza virus resistant to the novel camphor-based antiviral camphecene results in loss of viral pathogenicity. Virology, 524 (11):69–77. doi:10.1016/j.virol.2018.08.011
• Galochkina AV, Bollikanda RK, Zarubaev VV, Tentler DG, Lavrenteva IN, Slita AV, Chirra N, Kantevari S. Synthesis of novel derivatives of 7,8-dihydro-6H-imidazo[2,1-b][1,3]benzothiazol-5-one and their virus-inhibiting activity against influenza A virus. Arch. Pharm., 2018, 1-8. doi: 10.1002/ardp.201800225
• Marvadi SK, Sivakrishna V, Sinegubova EO, Volobueva AS, Esaulkova YL, Muryleva AA, Tentler DG, Zarubaev VV, Sriram D, Kantevari S. 5-Chloro-2-thiophenyl-1,2,3-triazolylmethyldihydro quinolines as dual inhibitors of Mycobacterium tuberculosis and Influenza virus: Synthesis and evaluation. Bioorg Med Chem Lett., 2019;9(18):2664-2669.
• Fedorova VA, Kadyrova RA, Slita AV, Muryleva AA, Petrova PR, Kovalskaya AV, Lobov AN, Zileeva ZR, Tsypyshev DO, Borisevich SS, Tsypysheva IP, Vakhitova JV, Zarubaev VV. Antiviral activity of amides and carboxamides of quinolizidine alkaloid (-)-cytisine against human influenza virus A(H1N1) and parainfluenza virus type 3. Natural Product Research, 2019. DOI: 10.1080/14786419.2019.1696791
• Volobueva AS, Egorova A, Galochkina AS, Ekins S, Zarubaev VV, Makarov VA. The Evolution of Pleconaril: modified O-alkyl linker analogs have biological activity towards Coxsackievirus B3 Nancy. Molecules, 2020, 25(6). pii: E1345. doi: 10.3390/molecules25061345.
• Ulomskiy EN, Ivanova AV, Gorbunov EB, Esaulkova IL, Slita AV, Sinegubova EO, Voinkov EK, Drokin RA, Butorin II, Gazizullina ER, Gerasimova EL, Zarubaev VV, Rusinov VL. Synthesis and biological evaluation of 6-nitro-1,2,4-triazoloazines containing polyphenol fragments possessing antioxidant and antiviral activity. Bioorg Med Chem Lett 2020. doi:10.1016/j.bmcl.2020.127216.
• Shekunov EV, Efimova SS, Yudintceva NM, Muryleva AA, Zarubaev VV, Slita AV, Ostroumova OS. Plant Alkaloids Inhibit Membrane Fusion Mediated by Calcium and Fragments of MERS-CoV and SARS-CoV/SARS-CoV-2 Fusion Peptides. Biomedicines. 2021;9(10):1434. doi: 10.3390/biomedicines9101434.
• Volobueva AS, Yarovaya OI, Kireeva MV, Borisevich SS, Kovaleva KK, Mainagashev IY, Gatilov YV, Ilyina MG, Zarubaev VV, Salakhutdinov NF. Discovery of New Ginsenol-like Compounds with High Antiviral Activity. Molecules, 2021, 26.
• Zarubaev VV, Garshinina AV, Volobueva AS, Slita AV, Yarovaya OI, Bykov VV, Leonov KA, Motov VS, Khazanov VA, Salakhutdinov NF. Optimization of application schedule of Camphecene, a novel anti-influenza compound, based on its pharmacokinetic characteristics. Fundamental and Clinical Pharmacology, 2022;36(3):518-525. Doi: 10.1111/fcp.12750
• Mazdida Sulaiman, Vladimir Zarubaev, Chandramathi Samudi, Mohammed Rahmatullah, Khoshnur Jannat, Alok Paul, Mogana Rajagopal, Malarvili Salvaraj, Veeranoot Nissapatorn, Monica Suleiman, Mark Butler, Christophe Wiart. Natural products from medicinal plants in Asia and the Pacific for RNA viruses: Hercules’ fifth labour. Pharmaceutical Biology, 2022, 60(1), 2049–2087. Doi: 10.1080/13880209.2022.2130944
• Sinegubova, E.O.; Kraevaya, O.A.; Volobueva, A.S.; Zhilenkov, A.V.; Shestakov, A.F.; Baykov, S.V.; Troshin, P.A.; Zarubaev, V.V. Water-Soluble Fullerene C60 Derivatives Are Effective Inhibitors of Influenza Virus Replication. Microorganisms 2023, 11, 681. Doi: 10.3390/microorganisms11030681
• Borisevich SS, Zarubaev VV, Shcherbakov DN, Yarovaya OI, Salakhutdinov NF. Molecular Modeling of Viral Type I Fusion Proteins: Inhibitors of Influenza Virus Hemagglutinin and the Spike Protein of Coronavirus. Viruses. 2023; 15(4):902. https://doi.org/10.3390/v15040902
• Shekunov EV, Zlodeeva PD, Efimova SS, Muryleva AA, Zarubaev VV, Slita AV, Ostroumova OS. Cyclic lipopeptides as membrane fusion inhibitors against SARS-CoV-2: New tricks for old dogs. Antiviral Res. 2023;212:105575. doi: 10.1016/j.antiviral.2023.105575.
• Smirnova, I.; Petrova, A.; Giniyatullina, G.; Smirnova, A.; Volobueva, A.; Pavlyukova, J.; Zarubaev, V.; Van Loc, T.; Tran Thi Phoung, T.; Hau, V.T.B.; Nguyen Thi Thu Thuy, Myint Myint Khine, Oxana Kazakova. Synthesis, Anti-Influenza H1N1 and Anti-Dengue Activity of A-Ring Modified Oleanonic Acid Polyamine Derivatives. Molecules 2022, 27, 8499. https://doi.org/10.3390/molecules27238499
• Lane TR, Fu J, Sherry B, Tarbet B, Hurst BL, Riabova O, Kazakova E, Egorova A, Clarke P, Leser JS, Frost J, Rudy M, Tyler KL, Klose T, Volobueva AS, Belyaevskaya SV, Zarubaev VV, Kuhn RJ, Makarov V, Ekins S. Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5. Antiviral Res. 2023;216:105654. doi: 10.1016/j.antiviral.2023.105654.

Научные проекты: